Orally administered insulin

Oral insulin formulation with peptide DDS technology for high intestinal absorption efficiency.

Treatment for Gaucher disease by inhibiting microglial phagocytosis-induced neuron death

Combination of microglia activation inhibitor and TNF blocker improve neuronopathic symptoms

Novel cancer immunotherapy antibodies targeting soluble CD155

Targeting soluble CD155, an immune escape mechanism of tumor cells, activates cancer immunity through DNAM-1-mediated activation signals on T cells

DDS to Activated Macrophages by Advanced Mannose Sugar Chain-loaded Human Serum Albumin

A system that selectively delivers drugs to macrophages in target tissues, such as tumor microenvironments, by means of advanced mannose sugar chain-loaded human albumin designed for the target tissue.

Treating Brain Injury with Endogenous Neurogenic Cells

Injection of self-assembling peptides into the brain, which serve as a cellular guide pathway, induces migration of neurons to the damaged area and activates neural regeneration.

CTL-inducing Vaccine for COVID-19

Peptide vaccine that induces CTLs (cytotoxic T cells) targeting the nucleocapsid-derived epitope of SARS-CoV-2.

Anti-Obesity and/or Anti-Diabetes Drug

Endogenous protein that promotes adipocyte activation (UCP1 expression promotion/mitochondrial activation).

Novel NASH Ex vivo Model using Hepatic Organoids Connected to Bile Ducts (HBTO)

IgG-type bispecific antibody

TribsMab CLC, a novel bispecific antibody format solves a manufacturing challenge

Novel therapeutic target for interstitial cystitis

Therapeutic mechanism that differs from conventional treatment methods with the target identified from genetic analysis of model animals and IC patients

Peptide drug for fibrosis

Designed RANKL fragment peptides (Partial agonist of RANKL) treat fibrosis.

Therapeutic Peptide for Autoimmune Diseases

A small peptide that inhibits interaction between STAP-2 and TCR and exhibits immunosuppressive effects.

STAP-2 Inhibitory Small Peptide for Cancer Treatment

STAP-2 Inhibitory peptide suppresses tumor growth by inhibiting EGFR-STAP-2 interaction and promoting EGFR degradation.

Novel Therapeutic Targets for Osteoporosis and/or Osteogenesis Stimulants

A protein with the ability to both inhibit osteoclast differentiation and promote osteoblast differentiation

A new concept for the treatment of allergic dermatitis by targeting glycan receptors on macrophages

Inhibition of TLR4-dependent allergic inflammatory response by Asialoglycoprotein receptor (Asgr1) glycan ligands

Novel PEGylation keeping high protein activity

Single Step Reaction, No Need of Genetic Modification

Liver organoid model containing human hepatocytes for pharmacokinetic assay

Original method and hepatocyte reproduced hepatobiliary function

Peptide Drug for psoriasis

RANKL fragment peptides treat psoriasis with reduced expression of inflammatory cytokines through Toll-like receptor 7/8 (TLR7/8) signaling pathway.

Neuro-protectant Peptides for Ischemic Stroke

Fragmentation of RANKL Eliminates Side-effect while Boosting Effect.