Advantages
- Higher bone induction ability than conventional BMP + scaffolding material (collagen sponge).
> Treatment with lower BMP2 concentrations is possible. - Clinically simple (only mix it with bones before graft).
- Various growth factor can be combined.
- Treatment by systemic administration is also possible (for osteoporosis).
- Combination of ingredients with a proven clinical history.
Current Stage and Key Data
- Early preclinical research stage.
- Artificial bone impregnated with LMWH-D8 and BMP-2 (2 μg) formed bone without any gaps between the bone and the host bed.
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Partnering Model
- Seeking an exclusive license partner
Background and Technology
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In the treatment of intractable fractures and spinal fixation, early bone union (bone regeneration) is important for the patient’s QOL. Conventional bone regeneration methods include autologous bone grafts, artificial bone (bone substitute), allogeneic/xenogeneic bone grafts, BMP + scaffolding materials, and cell therapy, but each method has issues such as invasiveness, bone induction, rejection, treatment costs, and safety. In Europe and the United States, BMP-2 has been approved and is used in combination with absorbable collagen sponge as a scaffolding material. However, the treatment costs are high, and high-concentration administration is required because BMP is released quickly and diffuses, and problems such as swelling and ectopic ossification have been pointed out.
It is known that BMP binds to polysulfated glycans (low molecular weight heparin or chondroitin sulfate E), and that aspartic acid peptide (Asp-8) specifically binds to bone. We have developed a molecule (LMWH-D8) that combines polysulfated glycans and Asp-8 by utilizing these properties. The complex of BMP and LMWH-D8 delivers, accumulates, and maintains the concentration of BMP around the bone, promoting bone formation.
Principal Investigator
Satoshi NOZAWA (Orthopedic Surgery, School of Medicine, Gifu University)
Patent
- PCT Patent application: Publication No. WO 2024/080183
Project.BK-04600