Novel target molecules of the ergosterol synthesis pathway, a critical gene for Candida
Cell membrane-derived vesicles of target bacteria can be used to develop activation products for specific enteric bacteria and antibacterial agents against biofilm-producing bacteria
Safe molecular design that allows RI to be rapidly excreted into the urine by providing a tubule-specific enzyme cleavage sequence between the RI chelating site and the antibody
Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]
Oral DDS technology using cyclic peptides of D-amino acids that can reach the small intestine while suppressing degradation in the digestive tract and allowing highly efficient permeation through the intestinal epithelium.
Synthetic tools & know-how using "hydrazide" that can synthesize versatile peptide intermediates
Cyclic pyrrole-imidazole polyamide (cPIP) selectively suppresses expression of pathogenic RNA in CAG/CTG triplet repeat neurological diseases.
For acute kidney injury, inflammatory bowel disease, depressions, etc.
RNA-binding molecules, such as antisense oligonucleotides and small molecules, facilitate back-splicing progression and augment circular RNA
Therapeutic target molecules and antisense oligonucleic acid (ASO) therapeutic agents for autosomal dominant polycystic kidney disease (ADPKD).