A chain molecule in which peptide nucleic acid (PNA) strands are bound to both ends of a peptide strand to form a cyclic peptide. A bulge-shaped cyclic peptide structure is formed by forming a PNA/PNA duplex with a complementary PNA strand.
Orally available nanoparticles containing BCAA peptides
Nanoparticles Comprising Polylysine Dendrimer Derivatives, Anionic Polymers, and Nucleic Acids
A cyclic peptide for highly efficient delivery into the brain with macromolecular drugs.
Collaborative research proposals using this discovery platform.
This technology utilizes small-molecule ligands that enhance the efficacy of oligonucleotide therapeutics in reducing gene expression within the spleen.
D35LNPs stimulate TLR9 and significantly induce the release of IFN-α from plasmacytoid dendritic cells, thereby strongly enhancing systemic immunity
Using vesicles derived from the cell membrane of target bacteria allows for highly species-specific treatment
Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]
Oral DDS technology using cyclic peptides of D-amino acids that can reach the small intestine while suppressing degradation in the digestive tract and allowing highly efficient permeation through the intestinal epithelium.
Newly designed KK-(EK)4-lipid having near neutral charge enhances intracellular translocation of drug carrier
Original method and hepatocyte reproduced hepatobiliary function
One Step N-Terminal Conjugation of Functional Compounds
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