Intraoral Irrigation Device for Patients Undergoing Treatment for Medication-Related Jawbone Necrosis (MRONJ)

A mouthpiece-type irrigation device designed for home use by patients themselves.

11-Amino-Acid Antifungal Peptide Drug from Plant Defensins

Expected to be effective against a wide range of fungal species through a mechanism of action different from existing drugs

Application for Early Detection of Aortic Stenosis

Screening for asymptomatic AS by quantifying aortic valve calcification (Agatston score) from routine body CT scans.

in planta Genome Editing

A Simple and Efficient Genome Editing Tool via Transient Protein Expression

Exitron-ASO for ALS/FTLD: Suppressing Aggregation while Maintaining a Function in Nucleus

This antisense oligonucleotide (ASO) sterically blocks the binding hotspots of RNA-binding proteins to reactivate the splicing of an "exitron" within the TDP-43 gene. As a result, it reduces the production of the Intrinsically Disordered Region (IDR) that triggers aggregation, while simultaneously increasing a protective short isoform (ΔIDR). This isoform guides TDP-43 aggregates to be processed via a "Cap & Escort" mechanism. This approach simultaneously achieves the typically conflicting goals of suppressing cytoplasmic aggregation and restoring nuclear function.

A Plate Culture System for Maintaining a Homeostatic Gas Environment During Incubation

An electricity-free pump powered by shaking motion automatically supplies gas, while a specialized plate suppresses evaporation to create an ideal culture environment.

Derivative Screening Technology for Peptide Drug Development

A novel peptide scanning process capable of significantly reducing the time

Acute Myeloid Leukemia (AML) Treatment

Marker molecules showing resistance to FLT3 inhibitors in FLT3-mutated AML cells, and FLT3 inhibitor sensitizers targeting these molecules.

Proposal for co-development of MOGAD(MOG antibody-associated disease) diagnosis and differentiation

Testing Models for Male Reproductive Toxicity

Model mice transfected with reporter genes involved in spermatogenesis