Safe molecular design that allows RI to be rapidly excreted into the urine by providing a tubule-specific enzyme cleavage sequence between the RI chelating site and the antibody
Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]
Oral DDS technology using cyclic peptides of D-amino acids that can reach the small intestine while suppressing degradation in the digestive tract and allowing highly efficient permeation through the intestinal epithelium.
Synthetic tools & know-how using "hydrazide" that can synthesize versatile peptide intermediates
For acute kidney injury, inflammatory bowel disease, depressions, etc.
RNA-binding molecules, such as antisense oligonucleotides and small molecules, facilitate back-splicing progression and augment circular RNA
Therapeutic target molecules and antisense oligonucleic acid (ASO) therapeutic agents for autosomal dominant polycystic kidney disease (ADPKD).
Peptide linker enhances the interaction between VH-VL within scFv molecules, which suppresses intermolecular association.
A novel therapeutic approach for systemic anti-tumor immunity utilizing apolipoproteins
Splice-switching antisense oligonucleotides (SSOs) targeting the α-synuclein (SNCA) gene suppress α-synuclein (α-Syn) aggregation.
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