Microglia Specific AAV Vector

For Gene Therapy Use and Disease Research Animal Model Establishment

Development of gene or mRNA therapy for arrhythmogenic right ventricular cardiomyopathy (ARVC)

Proposed collaboration to develop ARVC therapies (e.g., gene therapy or mRNA therapy) using PKP2 mutant disease model cells from ARVC patients and corresponding recovery cells.

Proposal for co-development of glycolipid therapeutics for inflammatory diseases (IBD, SLE)

Controlling inflammation by regulating T cell ganglioside content with glycolipid GlcCer containing nanoparticle formulation (GlcCer-LNP)

Epigenome editing, a CRISPR therapy modulating DNA methylation

Proposal for platform construction and development of drugs for rare genetic diseases

Type 1 Diabetes Treatment

Protection and regeneration of β cells by gene therapy

A new concept for the treatment of allergic dermatitis by targeting glycan receptors on macrophages

Inhibition of TLR4-dependent allergic inflammatory response by Asialoglycoprotein receptor (Asgr1) glycan ligands

Efficient method for the production of liposomes containing hydrophilic substances

Efficient encapsulation of hydrophilic small molecules and medium molecular weight drugs such as nucleic acids and peptides in liposomes

Improving the efficiency of exogenous mRNA expression

Overcoming the challenges of mRNA medicine by improving translation efficiency

HB-EGF: Liver Protection and Regeneration Drug

Anti-cell death, anti-fibrosis and induced-regeneration in fulminant hepatic failure and many kinds of Intractable liver diseases.

Liver organoid model containing human hepatocytes for pharmacokinetic assay

Original method and hepatocyte reproduced hepatobiliary function

Virus agent for treatment of Fibrosis

Repositioning reovirus, which has been developed as an anti-cancer drug.

Precise, Efficient Somatic Cell CRISPR HDR Gene Correction

Useful for gene therapy by minimizing non-homologous end joining (NHEJ) derived Insertions or deletions (Indels)

Cancer vaccine (gene therapy) using adenoviral vector (Ad-REIC)