Genome editing treatment of retinitis pigmentosa using the Crispr system, which can be carried on a single AAV

Compact vector design and highly efficient gene knock-in achieved by combining microhomology-mediated end-repair pathway (MMEJ) and homologous recombination-independent specific gene insertion (HITI)

mRNA drug stabilizer

Inhibits OAS3/RNaseL, an intracellular mechanism for degradation of exogenous RNA, stabilizing the mRNA and improving the expression efficiency of the target protein

Development of gene or mRNA therapy for arrhythmogenic right ventricular cardiomyopathy (ARVC)

Proposed collaboration to develop ARVC therapies (e.g., gene therapy or mRNA therapy) using PKP2 mutant disease model cells from ARVC patients and corresponding recovery cells.

A new concept for the treatment of allergic dermatitis by targeting glycan receptors on macrophages

Inhibition of TLR4-dependent allergic inflammatory response by Asialoglycoprotein receptor (Asgr1) glycan ligands

Improving the efficiency of exogenous mRNA expression

Overcoming the challenges of mRNA medicine by improving translation efficiency

Liver organoid model containing human hepatocytes for pharmacokinetic assay

Original method and hepatocyte reproduced hepatobiliary function

Virus agent for treatment of Fibrosis

Repositioning reovirus, which has been developed as an anti-cancer drug.

Precise, Efficient Somatic Cell CRISPR HDR Gene Correction

Useful for gene therapy by minimizing non-homologous end joining (NHEJ) derived Insertions or deletions (Indels)

Cancer vaccine (gene therapy) using adenoviral vector (Ad-REIC)