Compact vector design and highly efficient gene knock-in achieved by combining microhomology-mediated end-repair pathway (MMEJ) and homologous recombination-independent specific gene insertion (HITI)
Inhibits OAS3/RNaseL, an intracellular mechanism for degradation of exogenous RNA, stabilizing the mRNA and improving the expression efficiency of the target protein
Proposed collaboration to develop ARVC therapies (e.g., gene therapy or mRNA therapy) using PKP2 mutant disease model cells from ARVC patients and corresponding recovery cells.
Inhibition of TLR4-dependent allergic inflammatory response by Asialoglycoprotein receptor (Asgr1) glycan ligands
Overcoming the challenges of mRNA medicine by improving translation efficiency
Original method and hepatocyte reproduced hepatobiliary function
Repositioning reovirus, which has been developed as an anti-cancer drug.
Useful for gene therapy by minimizing non-homologous end joining (NHEJ) derived Insertions or deletions (Indels)