A Novel Drug Discovery Approach Targeting a Macrophage-Derived Cytokine and Its Downstream Molecules That Induce Cartilage Destruction
A cyclic peptide for highly efficient delivery into the brain with macromolecular drugs.
Discovery of a new mechanism of hypertension induction and proposal for drug discovery collaboration based on the mechanism.
Detection and early diagnosis of patients with rheumatoid arthritis who are negative for existing blood markers
Orally available micelle-type branched-chain amino acid prodrug
A drug candidate for the treatment of various fibrosis, incorporating a ligand for RIG-I, a pattern recognition receptor, as the active ingredient.
A new concept in therapeutics targeting molecules associated with vascular inflammation
Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]
For acute kidney injury, inflammatory bowel disease, depressions, etc.
Peptide linker enhances the interaction between VH-VL within scFv molecules, which suppresses intermolecular association.
A new therapeutic concept to prevent cellular infiltration into inflamed tissues by targeting the nets structures (Myl9-nets) generated in the lumen of blood vessels.
Oral insulin formulation with peptide DDS technology for high intestinal absorption efficiency.
Therapeutic mechanism based on enhancement of adipocyte activation (promotion of UCP1 expression and mitochondrial activation) by SerpinA1.
TribsMab CLC, a novel bispecific antibody format solves a manufacturing challenge
Therapeutic mechanism that differs from conventional treatment methods with the target identified from genetic analysis of model animals and IC patients
Designed RANKL fragment peptides (Partial agonist of RANKL) treat fibrosis.
Blockade of novel target, Netrin-4 Unc5B signaling.
Treatment of allergies and mastocytoma with Mast cell targeting antibodies
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