Novel ALS Therapeutic Target Identified from Motor Neuron Pathology: mGluR5

Discovery of mGluR5 dysfunction in ALS patients with TDP-43 pathology offers a new direction for the development of disease-modifying therapies

11-Amino-Acid Antifungal Peptide Drug from Plant Defensins

Expected to be effective against a wide range of fungal species through a mechanism of action different from existing drugs

Exosome Drug for Anti-aging

Life-extending effects confirmed in mice by using the sensor molecule CtBP2, which has broad metabolic activation effects such as improving diabetes, as a payload.

Therapeutic and Prophylactic Drugs for Idiopathic Osteonecrosis of the Femoral Head (ONFH)

Therapeutic and Prophylactic Drugs for Idiopathic Osteonecrosis of the Femoral Head (ONFH)

Branched Chain Amino Acid Prodrug to Increase Muscle and Reduce Fat

Orally available nanoparticles containing BCAA peptides

Mast Cell Line Capable of Cytokine-Free Proliferation

A High-Performance Evaluation Tool Overcoming the Limitations of conventional cells

Rheumatoid Arthritis Therapeutics Targeting the Inflammatory Cytokine Sema4D signaling

A Novel Drug Discovery Approach Targeting a Macrophage-Derived Cytokine and Its Downstream Molecules That Induce Cartilage Destruction

Blood-Brain Barrier DDS Peptide

A cyclic peptide for highly efficient delivery into the brain with macromolecular drugs.

Macrophages as Drug Targets for Hypertension Treatment

Discovery of a new mechanism of hypertension induction and proposal for drug discovery collaboration based on the mechanism.

Citrullinated ITIH4: Biomarkers of RA diagnosis and treatment responsiveness

Detection and early diagnosis of patients with rheumatoid arthritis who are negative for existing blood markers

Collaborative research on invasive epithelial cells in the precancerous state in interstitial pneumonia and the development of therapeutic agents

Amino Acid Prodrug to Increase Muscle Mass and Enhance Exercise Performance

Orally available micelle-type branched-chain amino acid prodrug

Therapeutics for Fibrosis Targeting RIG-I

A drug candidate for the treatment of various fibrosis, incorporating a ligand for RIG-I, a pattern recognition receptor, as the active ingredient.

Therapeutic Antibody for Pulmonary Hypertension Targeting Myl9/12

A new concept in therapeutics targeting molecules associated with vascular inflammation

Novel Drug Target for Endometriosis

Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]

Keton Body BHB Nanoparticle Prodrug

For acute kidney injury, inflammatory bowel disease, depressions, etc.

scFv Stabilization Peptide Linker

Peptide linker enhances the interaction between VH-VL within scFv molecules, which suppresses intermolecular association.

Therapeutic antibodies targeting Myl9/12 for chronic inflammatory diseases

A new therapeutic concept to prevent cellular infiltration into inflamed tissues by targeting the nets structures (Myl9-nets) generated in the lumen of blood vessels.

Anti-Obesity and/or Anti-Diabetes Drug

Therapeutic mechanism based on enhancement of adipocyte activation (promotion of UCP1 expression and mitochondrial activation) by SerpinA1.

Novel NASH Ex vivo Model using Hepatic Organoids Connected to Bile Ducts (HBTO)