Small Molecule Myosin Activator for Heart Failure

First-in-class Inotrope candidate for Patients with HFrEF

A candidate compound for promoting bone formation

Runx2 expression was specifically induced in osteoblasts. Bone volume was increased through the enhanced bone formation in mice.

Screening for colorectal cancer by measuring proteins in urine

Measurement of Two Markers in urine samples enables colorectal cancer risk diagnosis with sensitivity: 94.3%, specificity: 63.4%, AUC=0.870.

Biomarkers of PARP Inhibitor Response in Ovarian Cancer

Gene copy number profile of extracellular vesicles in body fluid to determine the sensitivity of ovarian cancer to the anticancer drug PARP inhibitors.

Proposal for a project to establish imaging technology for male infertility through the application of MRI technology

Anti-Obesity and/or Anti-Diabetes Drug

Therapeutic mechanism based on enhancement of adipocyte activation (promotion of UCP1 expression and mitochondrial activation) by SerpinA1.

Novel NASH Ex vivo Model using Hepatic Organoids Connected to Bile Ducts (HBTO)

Atrial Fibrillation Risk/Severity Diagnostic Device

Device equipped with an AI program that can diagnose the risk and severity of paroxysmal atrial fibrillation from as little as 30 consecutive beats of ECG data.

Induction of highly purified differentiation of endothelial progenitor cells (EPCs) from iPS cells and BBB model using brain microvascular endothelial-like cells (iBMELCs)

Optimized induction of iBMELCs differentiation from iPS cell-derived vascular endothelial progenitor cells (iEPCs) successfully induced cells with gene expression and barrier function like human BMECs.

Cancer therapy targeting cellular senescence

Novel therapeutic approach targeting the release mechanism of senescence-associated secretory phenotype (SASP) factors from senescent cells