A novel analyzing method for DNA molecules of size greater than 10 kbp by measuring DNA relaxation time with micro/nanofluidic devices
1) Modified phosphoramidite method 2) Efficient Flow Synthesis System
Useful for gene therapy by minimizing non-homologous end joining (NHEJ) derived Insertions or deletions (Indels)
Achieved targeted large size gene knock-in animal production.
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