Summary of the technology
The 26S proteasome is an essential component of the ubiquitin-proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins. In eukaryotes, the 20S proteasome contains seven alpha-type subunits and seven beta-type subunits. And inventors established 3 types of antibodies that recognize several subunits of the 20S proteasome from goldfish ovary.
Features of these antibodies are as follows:
- The antibodies can recognize proteasome of ALL organisms such as yeast, fish, frog, rat, human and plants.
- One type of the antibodies can be applicable to Immunoelectron microscopy because it can recognize several subunits of 20S proteasome.
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| Rat sperm | Human sperm |
Inventor :
Prof. Toshinobu Tokumoto (Shizuoka University)
Publication:
- Tokumoto et al. Two proteins, a goldfish 20S proteasome subunit and the protein interacting with 26S proteasome, change in the meiotic cell cycle. Eur J Biochem. 2000 Jan;267(1):97-103.
- Yokota et al. Possible function of caudal nuclear pocket: degradation of nucleoproteins by ubiquitin-proteasome system in rat spermatids and human sperm. J Histochem Cytochem. 2007 Jun;55(6):585-95.
Proposal :
We are seeking a company who produces and sells above three kinds of mAbs. Each Hybridoma cells that produces 20S proteasome mAbs are available under MTA.
Product No: TP0263