Selective Medium for Carbapenem-Non-Susceptible Viridans Group Streptococci

Identification method and selection medium for viridans group streptococci (VGS) resistant/non-susceptible to β-lactam antibiotics including carbapenems.


  • A selective medium that can specifically culture only carbapenem-non-susceptible VGS.
  • Carbapenem susceptibility can be confirmed when using antibiotics for VGS.
  • If nosocomial infection of carbapenem-non-susceptible VGS is suspected, the source can be determined by culturing the collected sample.

Background and Technology

Viridans group streptococci (VGS) are Gram-positive bacteria that can reside in the oral cavity and can be the causative bacteria of infective endocarditis. Among the beta-lactam antibiotics used to treat VGS infections, bacteria resistant to penicillins and cephalosporins have been confirmed, and in such cases, carbapenems are used as a trump card.
We identified for the first time 25 VGS strains that are non-susceptible to carbapenems in the clinic. It was confirmed that these carbapenem-non-susceptible VGS also show reduced susceptibility to many other β-lactam antibiotics. At present, there are few reports of clinical detection of carbapenem- non-susceptible VGS, but there is concern that this will spread and become a problem in the future. Therefore, when using antibiotics for VGS, it is important to confirm carbapenem susceptibility.
We analyzed the susceptibility of the identified carbapenem-non-susceptible VGS strains to various antibacterial drugs using the disk diffusion method and developed a detection method using the disk diffusion method and a selective medium.

Reference and Patent

Principal Investigator

Kouji KIMURA (Nagoya University Graduate School of Medicine)

Current Stage and Next Step

  • To date, we have developed a detection method and selection medium composition for carbapenem-non-susceptible VGS.
  • The specific detection methods and the selection media details can be disclosed under CDA.
  • We are looking for partner companies for collaboration regarding the commercialization of the selective media and the incorporation into automatic antimicrobial susceptibility testing systems.



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