{"id":4979,"date":"2025-11-27T13:25:26","date_gmt":"2025-11-27T04:25:26","guid":{"rendered":"https:\/\/bionauts.jp\/?p=4979"},"modified":"2025-12-04T22:25:58","modified_gmt":"2025-12-04T13:25:58","slug":"antiviral-drug-against-dengue-virus-and-zika-virus","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=4979","title":{"rendered":"Antiviral Drug against Dengue Virus and Zika Virus"},"content":{"rendered":"<h3>Advantage<\/h3>\n<ul>\n<li>Potent antiviral activity against a wide range of virus species, including Dengue virus, Zika virus, and SARS-CoV-2.<\/li>\n<li>The compound prevents viral replication via the inhibition of virus-dependent RNA polymerase<\/li>\n<\/ul>\n<h3>Current Stage and Key Data<\/h3>\n<p>Lead compound optimization<\/p>\n<ul>\n<li>The compound demonstrated <em>in vitro<\/em> antiviral activity against SARS-CoV, SARS-CoV-2, two types of human coronaviruses (strain 229E and OC43), Dengue virus, Zika virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus.<\/li>\n<li>The compound improved survival rate and inhibited viral replication in Dengue virus infection model mice and SARS-Cov2 infection model mice.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 75.6667%; height: 449px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/11\/BK-04122b_lower_EN.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4980\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/11\/BK-04122b_lower_EN.png\" alt=\"\" width=\"528\" height=\"493\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/11\/BK-04122b_lower_EN.png 528w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/11\/BK-04122b_lower_EN-300x280.png 300w\" sizes=\"(max-width: 528px) 85vw, 528px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Partnering Model<\/h3>\n<p>Seeking partner companies to work on optimizing this compound, as well as conducting non-clinical and clinical trials.<\/p>\n<ul>\n<li>Potential partners: Pharmaceutical\/Biotech companies focused on developing drugs to treat viral infections or NTDs.<\/li>\n<\/ul>\n<h3>Background<\/h3>\n<p>We have identified new compounds by screening nucleic acid antimetabolites with antiviral activity using a nucleic acid-like compound library in owned by the Research and Education Center for Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Hokkaido University. The new compounds\u3000exhibited high antiviral activity against positive-sense single-stranded RNA viruses such as coronavirus and flavivirus.<\/p>\n<h3>Patents<\/h3>\n<ul>\n<li>Patent pending : US, EP, JP, CN, KR, SG, CA<\/li>\n<\/ul>\n<h3>Principal Investigator<\/h3>\n<p>Akira Matsuda (Faculty of Pharmaceutical Science, Hokkaido University), et al.<\/p>\n<p>&nbsp;<\/p>\n<p>Project ID:BK-04122b<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A novel small molecule compound with high antiviral activity against flaviviruses and coronaviruses.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[100,96],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4979"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4979"}],"version-history":[{"count":2,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4979\/revisions"}],"predecessor-version":[{"id":4982,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4979\/revisions\/4982"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4979"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=4979"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=4979"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=4979"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=4979"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=4979"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=4979"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=4979"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=4979"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=4979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}