{"id":4797,"date":"2025-09-24T10:33:40","date_gmt":"2025-09-24T01:33:40","guid":{"rendered":"https:\/\/bionauts.jp\/?p=4797"},"modified":"2025-09-25T15:21:56","modified_gmt":"2025-09-25T06:21:56","slug":"personalized-tcr-t-nk-cell-therapy-for-cancer","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=4797","title":{"rendered":"Personalized TCR-T\/NK Cell Therapy for Cancer"},"content":{"rendered":"<h3>Advantages<\/h3>\n<ul>\n<li>Higher specificity for individual patient cancer antigens than conventional TCR-T\/NK cell therapy.<\/li>\n<li>Easier to produce than TIL (Tumor Infiltrating Lymphocyte) therapy.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 61.3333%; height: 193px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/09\/BK-05227_upper_EN.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-4799 size-full\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/09\/BK-05227_upper_EN.png\" alt=\"\" width=\"366\" height=\"289\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/09\/BK-05227_upper_EN.png 366w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/09\/BK-05227_upper_EN-300x237.png 300w\" sizes=\"(max-width: 366px) 85vw, 366px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Current Stage and Key Data<\/h3>\n<ul>\n<li>It has been confirmed that personalized TCRs can be efficiently identified by stimulating the patient&#8217;s peripheral blood cells with optimized NKT cells to induce and collect anti-tumor T cells.<\/li>\n<li>The therapeutic effect of induced anti-tumor T cells has been confirmed.<\/li>\n<\/ul>\n<h3>Partnering Model<\/h3>\n<p>We are seeking partnerships with companies developing cancer immune cell therapies. We are open to joint research and commercial licensing.<\/p>\n<ul>\n<li>Potential partner examples: Pharmaceutical\/biotech companies focusing on NTK cell therapy, TCR-T\/NK cell therapy, and CAR-T\/NK cell therapy.<\/li>\n<\/ul>\n<h3>Background<\/h3>\n<p>TCR-T\/NK cell therapy, known as cancer immunotherapy, has the advantage over CAR-T cell therapy of being able to target intracellular molecules and being specific for tumor-specific peptides. However, while the TCRs were created by identifying peptides from the tumor&#8217;s overall genomic information, it was unclear whether they would match specific patients and tumors. Furthermore, TIL (Tumor Infiltrating Lymphocyte) therapy, known as a patient-specific T cell therapy, involves collecting lymphocytes that have infiltrated the patient&#8217;s tumor tissue, isolating, culturing, and expanding activated anti-tumor T cells, and then returning them to the body. However, the isolation, culturing, and expansion of activated anti-tumor T cells make for a complex production process.<\/p>\n<h3>Publications and Patents<\/h3>\n<ul>\n<li>Paper submission in preparation and patent pending (unpublished).<\/li>\n<\/ul>\n<h3>Principal Investigator<\/h3>\n<p>Takahiro AOKI (Medical Immunology, Graduate School of Medicine, Chiba University)<\/p>\n<p>&nbsp;<\/p>\n<p>Project ID:BK-05227<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A method of stimulating the peripheral blood of cancer patients with NKT cells, inducing and collecting anti-tumor T cells, and identifying cancer antigen-specific TCRs. A TCR-T\/NK cell therapy specific to the patient is then developed. Alternatively, the induced anti-tumor T cells can be used for treatment.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[109,110],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4797"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4797"}],"version-history":[{"count":2,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4797\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4797\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4797"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=4797"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=4797"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=4797"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=4797"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=4797"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=4797"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=4797"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=4797"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=4797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}