{"id":4617,"date":"2025-06-10T16:32:24","date_gmt":"2025-06-10T07:32:24","guid":{"rendered":"https:\/\/bionauts.jp\/?p=4617"},"modified":"2025-06-16T21:40:55","modified_gmt":"2025-06-16T12:40:55","slug":"cancer-metastasis-inhibitor","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=4617","title":{"rendered":"Cancer Metastasis Inhibitor"},"content":{"rendered":"<h3>Advantages<\/h3>\n<ul>\n<li>Identification of new target molecules and pathways for cancer metastasis<\/li>\n<li>Extending recurrence-free survival after localized treatment of oligometastatic cancer<\/li>\n<li>Personalized treatment with companion diagnostics<\/li>\n<\/ul>\n<h3>Current Stage and Key Data<\/h3>\n<p><u>Research stage of target molecules and mechanisms (discovery stage)<\/u><\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\">\n<ul>\n<li>Bone metastasis was suppressed in a bone metastasis model mouse that administered a cancer cell line in which the target molecule was knocked down with shRNA (right panel).<\/li>\n<li>Bone metastasis was suppressed by administering inhibitors of factors downstream of the target molecule.<\/li>\n<li>Identification of a group of marker molecules whose expression is increased or decreased in metastasis-initiating cells.<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 50%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-4622 size-large\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-1024x837.png\" alt=\"\" width=\"840\" height=\"687\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-1024x837.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-300x245.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-768x628.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-1536x1255.png 1536w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1-1200x981.png 1200w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221-1.png 1755w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Partnering Model<\/h3>\n<p><u>Collaborative research into screening and optimization of inhibitors of this target molecule (nucleic acids, small molecule compounds, etc.)<\/u><\/p>\n<ul>\n<li>Preferred indication: Extending recurrence-free survival after local therapy of oligometastatic breast cancer<\/li>\n<li>Examples of potential partners: Biotech\/pharmaceutical companies, Drug discovery companies<\/li>\n<\/ul>\n<h3>Background<\/h3>\n<p>In the development of bone metastatic tumors, metastasis initiating cells (MICs) remain dormant in bone tissue and are reactivated to form metastatic lesions, which are the root cause of metastatic recurrence. Therefore, it is believed that therapeutic strategies targeting MICs are the most effective way to prevent metastatic recurrence. However, the factors that determine the survival and reactivation of MICs have not been identified.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221a.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4624\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221a.png\" alt=\"\" width=\"560\" height=\"119\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221a.png 560w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/06\/BK-05221a-300x64.png 300w\" sizes=\"(max-width: 560px) 85vw, 560px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>We established a highly reproducible mouse model of bone metastasis with reactivation from metastatic latency and identified target molecules by analyzing an in vivo database in combination with human clinical samples. We confirmed that metastasis can be suppressed by using substances that inhibit the target molecules or their pathways.<\/p>\n<h2>Principal Investigator<\/h2>\n<p>Shinya Tanaka (Department of Cancer Pathology, Faculty of Medicine, Hokkaido University)<\/p>\n<h2>Reference<\/h2>\n<ul>\n<li>Paper: Unpublished<\/li>\n<li>Patent: Patent pending (unpublished)<\/li>\n<\/ul>\n<p>*Additional information can be disclosed under the CDA.<\/p>\n<p>&nbsp;<\/p>\n<p>Project ID:BK-05221<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Target molecules and their inhibitors that control the survival and reactivation of disseminated tumor cells (cancer metastasis-initiating cells).<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[105,108],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4617"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4617"}],"version-history":[{"count":4,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4617\/revisions"}],"predecessor-version":[{"id":4625,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4617\/revisions\/4625"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4617"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=4617"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=4617"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=4617"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=4617"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=4617"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=4617"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=4617"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=4617"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=4617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}