{"id":4468,"date":"2025-05-07T11:08:19","date_gmt":"2025-05-07T02:08:19","guid":{"rendered":"https:\/\/bionauts.jp\/?p=4468"},"modified":"2025-11-14T14:34:18","modified_gmt":"2025-11-14T05:34:18","slug":"branched-chain-amino-acid-prodrug-to-increase-muscle-and-reduce-fat","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=4468","title":{"rendered":"Branched Chain Amino Acid Prodrug  to Increase Muscle and Reduce Fat"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Combination of efficacy and safety proven ingredients and additive.<\/li>\n<li>Possibly useful for amyotrophic symptoms, such as sarcopenia, cachexia, muscle atrophies, dystrophies, as well as obesity.<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>Leucine Isoleucine, and Valine, collectively dubbed \u201cbranched chain amino acid (BCAA)\u201d are widely known to promote muscle synthesis and have been taken by athletes as supplements. However, its effects are limited probably because BCAA is easily excreted from the body.<br \/>\nTo overcome the drawback, the team of researchers has successfully synthesized a prodrug; BCAA peptide and polyethylene glycol block copolymer that forms micelles (Nano<sup>BCAA<\/sup>: Fig1). Orally administered Nano<sup>BCAA<\/sup> is trapped in the villi of intestine, gradually degraded by intestinal enzymes and releases BCAA. Moreover, Nano<sup>BCAA<\/sup> demonstrates fat reduction effect as well in vivo.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/05\/KJ-05045a.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4469\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/05\/KJ-05045a.png\" alt=\"\" width=\"905\" height=\"357\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/05\/KJ-05045a.png 905w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/05\/KJ-05045a-300x118.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/05\/KJ-05045a-768x303.png 768w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Data<\/h3>\n<ul>\n<li>20 nm Nano<sup>Leu<\/sup> was fabricated (Fig.1), and effects were confirmed in mouse model.<\/li>\n<li>Nano<sup>Leu <\/sup>free drink increased muscle strength over time, running capacity and muscle mass (Fig.2) after 4 weeks.<\/li>\n<li>Similar results obtained by Nano<sup>Ile<\/sup>, Nano<sup>Val<\/sup><\/li>\n<li>Nano<sup>BCAA<\/sup> demonstrated reduction in body (subcutaneous\/visceral) fat in mice (Fig.3).<\/li>\n<\/ul>\n<h3>Patent &amp;Publications<\/h3>\n<p>Patent: WO\/2025\/229946.<br \/>\nPartly presented in the Japan Society of DDS, 2024, etc.<\/p>\n<h3>Researchers<\/h3>\n<p>Dr. Yukio Nagasaki (University of Tsukuba)<br \/>\nDr. Nobuyuki Morimoto and Dr. Takuto Toriumi (Shimane University)<\/p>\n<h3>Expectations<\/h3>\n<p>We are seeking companies who can in-license and commercialize the technology.<br \/>\nDetails can be disclosed under CDA.<br \/>\nSamples are available under material transfer agreement.<\/p>\n<p>&nbsp;<\/p>\n<p>Project ID:KJ-05045a<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Orally available nanoparticles containing BCAA peptides 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