{"id":4388,"date":"2025-04-15T13:13:29","date_gmt":"2025-04-15T04:13:29","guid":{"rendered":"https:\/\/bionauts.jp\/?p=4388"},"modified":"2025-04-21T12:12:56","modified_gmt":"2025-04-21T03:12:56","slug":"ultrasensitive-sers-with-aligned-gold-colloidal-crystals","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=4388","title":{"rendered":"Ultrasensitive SERS with Aligned Gold Colloidal Crystals"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Simple New Surface Treatment: Instead of APTES, L-cysteine is used to modify the gold surface. This allows for a thinner insulator layer and keeps the electric field strong for better SERS signals.<\/li>\n<li>Higher Sensitivity Than Commercial Products: Can detect very small amounts of molecules (nM level). Shows 3\u20134 times better sensitivity than top commercial SERS chips.<\/li>\n<li>Many Possible Uses: Useful for drug discovery, detecting biomarkers and viruses, and testing food safety.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 50.5%; height: 81px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4394\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075.png\" alt=\"\" width=\"402\" height=\"286\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075.png 402w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075-300x213.png 300w\" sizes=\"(max-width: 402px) 85vw, 402px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Background and Technology<\/h3>\n<p>SERS (surface-enhanced Raman scattering) helps detect very small amounts of substances, and is used in biology, chemistry, and environmental fields. Gold colloidal crystals\u2014gold nanoparticles arranged in regular patterns\u2014are good materials for SERS, especially when they form strong \u201chotspots\u201d for the electric field.<br \/>\nOne way to improve SERS is to use a metal\u2013insulator\u2013metal (MIM) structure. But if the insulator is too thick, the signal becomes weak. The team first used TiO\u2082 as the insulator, which helped with colloid adsorption but didn\u2019t work well for SERS.<br \/>\nTo fix this, they used L-cysteine, which sticks to gold very well. It forms a very thin insulating layer, keeping the electric field strong. With this method, SERS signals became 17 times stronger than from normal glass-based chips. When using gold colloidal crystals instead of randomly placed particles, the signal was even stronger\u2014about 3\u20134 times better than the best commercial products.<\/p>\n<h3>Data<\/h3>\n<ul>\n<li>Random Adsorption on MIM (L-cys) Substrate: SERS signal was 17\u00d7 stronger than that from a glass substrate.<\/li>\n<li>Crystal Adsorption with Different Densities: When rhodamine was measured on L-cysteine-modified substrates with different densities of gold colloids, the signal was ~4\u00d7 higher than with random particles, and better than top commercial products.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 70.8333%; height: 166px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075a.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4389\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075a.png\" alt=\"\" width=\"521\" height=\"271\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075a.png 521w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075a-300x156.png 300w\" sizes=\"(max-width: 521px) 85vw, 521px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table style=\"border-collapse: collapse; width: 65.5%; height: 249px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075b.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-4390\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075b.png\" alt=\"\" width=\"422\" height=\"289\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075b.png 422w, https:\/\/bionauts.jp\/wp-content\/uploads\/2025\/04\/WL-05075b-300x205.png 300w\" sizes=\"(max-width: 422px) 85vw, 422px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Patent &amp; Publication<\/h2>\n<p>JP7079923B2, Others pending (not yet published)<\/p>\n<h2>Researcher<\/h2>\n<p>Dr. Junpei Yamanaka and Dr. Akiko Toyotama (Nagoya City University)<\/p>\n<h2>Expectations<\/h2>\n<p>We are looking for companies interested in testing this SERS substrate and developing it further. Test samples can be provided under a fee-based Material Transfer Agreement (MTA). Please contact us if you are interested.<\/p>\n<p>&nbsp;<\/p>\n<p>Project ID: WL-05075<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Enhanced SERS Sensitivity via Gold Colloid\u2013L-Cysteine\u2013Gold MIM Structures<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[47],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[],"other_than_medicine":[127,128,130,133],"material":[154],"engineering":[156],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4388"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4388"}],"version-history":[{"count":5,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4388\/revisions"}],"predecessor-version":[{"id":4396,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/4388\/revisions\/4396"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4388"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4388"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4388"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=4388"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=4388"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=4388"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=4388"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=4388"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=4388"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=4388"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=4388"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=4388"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}