{"id":3820,"date":"2024-07-24T11:54:41","date_gmt":"2024-07-24T02:54:41","guid":{"rendered":"https:\/\/bionauts.jp\/?p=3820"},"modified":"2025-07-31T14:44:55","modified_gmt":"2025-07-31T05:44:55","slug":"radiosensitizer-for-cancer-therapy","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=3820","title":{"rendered":"Radiosensitizer for Cancer Therapy"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Safety of low dose small molecule DCA has been evaluated by clinical trial.<\/li>\n<li>administration of Nanoparticle can be localized in cancer tissue.<\/li>\n<li>Oral administration can maintain blood concentration for a long time.<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>Dichloroacetic acid (DCA) is known to be a pyruvate dehydrogenase kinase inhibitor, which promotes mitochondrial electron transport chain and ROS generation, and result in cell death. \u00a0DCA has been developed for cancer treatment and examined the effect of irradiation sensitizer. However, DCA is not easy to use in clinical settings because DCA is easily excreted from the body and has neurotoxicity at high concentration.<br \/>\nTo overcome the drawback, the team of researchers has successfully synthesized prodrug, polyvinyl alcohol DCA ester and Polyethylene glycol block copolymer that forms micelles (Nano<sup>DCA<\/sup>), which accumulate in tumor tissues by extended permeation and release (EPR) effect, degrade and release DCA by endogenous enzyme (fig. L).<br \/>\nBy oral administration, Nano<sup>DCA<\/sup> is trapped by the villi of the intestine and gradually release DCA and maintains the blood concentration for a long time, which could be useful for the mitochondrial disease treatment for example.<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-3822\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2.png\" alt=\"\" width=\"1387\" height=\"404\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2.png 1387w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2-300x87.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2-1024x298.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2-768x224.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/07\/KJ-05025-2-1200x350.png 1200w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Data<\/h3>\n<ul>\n<li>200mg\/kg Nano<sup>DCA<\/sup> enhanced 5Gy x-ray radiation effect in tumor bearing mice (fig. R).<\/li>\n<li>DCA had some therapeutic effect, but not combination effects (data not shown).<\/li>\n<li>No weight loss observed.<\/li>\n<\/ul>\n<h3>Patent &amp;Publications<\/h3>\n<p>WO2025\/069980<br \/>\nPresented in the Japan Society of DDS 2024.<\/p>\n<h3>Researchers<\/h3>\n<p>Dr. Yukio Nagasaki (University of Tsukuba)<br \/>\nDr. Hironobu Yasui (Hokkaido University)<\/p>\n<h3>Expectations<\/h3>\n<p>We are seeking companies who can in-license and commercialize the technology.<br \/>\nDetails can be disclosed under CDA.<br \/>\nSamples are available under material transfer agreement.<\/p>\n<p>&nbsp;<\/p>\n<p>Project.KJ-05025<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dichloroacetate nanoparticle accumulates in cancer tissue by EPR effect.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[116,97,121,96],"other_than_medicine":[127,129],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3820"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3820"}],"version-history":[{"count":2,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3820\/revisions"}],"predecessor-version":[{"id":4671,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3820\/revisions\/4671"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3820"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3820"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3820"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=3820"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=3820"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=3820"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=3820"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=3820"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=3820"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=3820"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=3820"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=3820"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}