{"id":3476,"date":"2024-03-12T10:21:32","date_gmt":"2024-03-12T01:21:32","guid":{"rendered":"https:\/\/bionauts.jp\/?p=3476"},"modified":"2025-02-12T13:25:54","modified_gmt":"2025-02-12T04:25:54","slug":"keton-body-bhb-nanoparticle-prodrug","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=3476","title":{"rendered":"Keton Body BHB Nanoparticle Prodrug"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>beta-hydroxybutyrate (BHB) is known to be effective for AKI and other diseases.<\/li>\n<li>Nano<sup>BHB<\/sup> gradually degrades and release BHB and maintain concentration.<\/li>\n<li>Effect confirmed by AKI, IBD, depression animal models.<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>beta-hydroxybutyrate (BHB), one of the ketone bodies, participates in various signaling pathways (e.g., energy metabolism, inflammation reactions), thereby its supplement brings benefits to the treatment of many diseases; acute kidney injury, inflammatory bowel disease, Alzheimer\u2019s dementia, Parkinson\u2019s disease, post-traumatic stress disorder, depression, etc. However, BHB is not easy to use in clinical settings because BHB is easily excreted from the body.<\/p>\n<p>To overcome the drawback, the researcher has successfully synthesized prodrug, which is composed of poly BHB and Polyethylene glycol that forms micelles (Nano<sup>BHB<\/sup>), biodegradable by endogenous enzyme and sustainably release BHB.\u200b<\/p>\n<table style=\"border-collapse: collapse; width: 42.3333%; height: 126px;\">\n<tbody>\n<tr style=\"height: 67px;\">\n<td style=\"width: 100%; height: 67px;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-medium wp-image-3509\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e-300x63.jpg\" alt=\"\" width=\"300\" height=\"63\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e-300x63.jpg 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e-1024x215.jpg 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e-768x161.jpg 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/895328e37d9f95f73047cf7c316c078e.jpg 1178w\" sizes=\"(max-width: 300px) 85vw, 300px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Data<\/h3>\n<ul>\n<li>Nano<sup>BHB<\/sup>, not BHB, alleviated symptoms of cisplatin-induced acute kidney injury mice.<\/li>\n<li>No cytotoxicity observed in in-vitro analysis.<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/KJ-04711b-1.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-3483\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/KJ-04711b-1.png\" alt=\"\" width=\"681\" height=\"450\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/KJ-04711b-1.png 681w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/03\/KJ-04711b-1-300x198.png 300w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>\u200bPatent<\/h3>\n<p>PCT\/JP2024\/019499<\/p>\n<h3>Researcher<\/h3>\n<p>Dr. Yukio Nagasaki (University of Tsukuba)<\/p>\n<h3>Expectations<\/h3>\n<p>We are seeking companies who are interested in in-licensing and commercialization.<\/p>\n<p>Samples are available under material transfer agreement.<\/p>\n<p>&nbsp;<\/p>\n<p>Project No. KJ-04711<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>For acute kidney injury, inflammatory bowel disease, depressions, etc.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[50,46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[102,104,121,112],"other_than_medicine":[144,145,141],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3476"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3476"}],"version-history":[{"count":14,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3476\/revisions"}],"predecessor-version":[{"id":4219,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3476\/revisions\/4219"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3476"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3476"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3476"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=3476"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=3476"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=3476"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=3476"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=3476"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=3476"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=3476"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=3476"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=3476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}