{"id":3424,"date":"2024-02-29T14:07:15","date_gmt":"2024-02-29T05:07:15","guid":{"rendered":"https:\/\/bionauts.jp\/?p=3424"},"modified":"2024-03-02T00:52:36","modified_gmt":"2024-03-01T15:52:36","slug":"inducer-for-systemic-anti-tumor-immunity","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=3424","title":{"rendered":"Inducer for Systemic Anti-tumor Immunity"},"content":{"rendered":"<h3><strong>Advantages<\/strong><\/h3>\n<ul>\n<li>Demonstrated anti-tumor effects at the target lesions and non-target lesions.* Non target lesions are non-administered site of the drug.<\/li>\n<li>May be applicable in any case because of the activation of anti-tumor immunity without the necessity of adjuvants, neoantigens, or T cell modification.<\/li>\n<\/ul>\n<h3><strong>Technology Overview &amp; Background<\/strong><\/h3>\n<p>Numerous caner immunotherapies have been developed. The basic concept is to maintain the activity and number of T cells that attack tumor cells. However, the prevalence of non-responsive cases and the need for personalized treatment strategies underscore the scarcity of actively inducive anti-tumor immunity therapies.<\/p>\n<p>During research into anti-cancer medications, researchers unearthed the unique properties in anti-tumor immunity of apolipoproteins, particularly ApoD. Furthermore, it was revealed that ApoD significantly enhances and stimulates tumor-specific T cells in conjunction with T cell activators such as anti-OX40 agonist antibodies. These activated T cells exhibit anti-tumor effects on distant cancers by migrating, rendering this approach a potentially effective treatment for metastatic cancers. Additionally, the capability of apolipoproteins to increase and activate tumor-specific T cells suggests its potential universality against various tumor types because of its mechanism. This research result will lead to the promising drug for combatting metastatic cancer regardless of its origin.<\/p>\n<h3><strong>Patent<\/strong><\/h3>\n<ul>\n<li><a href=\"https:\/\/patentscope2.wipo.int\/search\/ja\/detail.jsf?docId=WO2022059703&amp;_cid=JP1-LSOQBA-01514-1\">PCT\/JP2021\/033925<\/a> (Entered into JP, US and EP)<\/li>\n<\/ul>\n<h3><strong>Principal Investigator &amp; Academic Institution<\/strong><\/h3>\n<p>Prof. Keisuke NIMURA (Initiative for Advanced Research, Gunma University)<\/p>\n<h3><strong>Development Stages &amp; Plans<\/strong><\/h3>\n<ul>\n<li>Current stage\uff1a<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">Intratumoral administration of Apod protein demonstrated anti tumor effect in tumor-bearing model mice.<\/p>\n<p style=\"padding-left: 40px;\">Intratumoral administration of Apod protein and OX40 agonist antibody strongly inhibited tumor growth not only at the administration site but also at a distant non-tumor site (Figure). The number of T cells increased significantly at the administered and non-treated sites.<br \/>\nResearcher newly elucidated a systemic anti-tumor mechanism of apolipoprotein.<\/p>\n<ul>\n<li style=\"text-align: left;\">Next Step\uff1a<\/li>\n<\/ul>\n<p style=\"padding-left: 40px; text-align: left;\">We can set up a meeting with the PI to discuss collaboration or R&amp;D.<br \/>\nAdditional data can be disclosed under CDA.<\/p>\n<table class=\" alignleft\" style=\"border-collapse: collapse; width: 57%; height: 214px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-3425\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514-1024x769.png\" alt=\"\" width=\"440\" height=\"331\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514-1024x769.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514-300x225.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514-768x577.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514-1200x901.png 1200w, https:\/\/bionauts.jp\/wp-content\/uploads\/2024\/02\/TT-03514.png 1416w\" sizes=\"(max-width: 440px) 85vw, 440px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><strong>Expectations<\/strong><\/h3>\n<p><u>TECH MANAGE CORP.<\/u> is looking for a pharmaceutical company\/start-up that is interested in licensing this invention for commercialization on behalf of the University. We can also arrange a meeting with the PI of this invention. Please feel free to contact us with any requests you may have.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Project No. TT-03514<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A novel therapeutic approach for systemic anti-tumor immunity utilizing apolipoproteins<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[102,103,121,112],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3424"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3424"}],"version-history":[{"count":7,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3424\/revisions"}],"predecessor-version":[{"id":3432,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3424\/revisions\/3432"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3424"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3424"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3424"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=3424"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=3424"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=3424"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=3424"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=3424"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=3424"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=3424"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=3424"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=3424"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}