{"id":3235,"date":"2023-11-20T10:33:32","date_gmt":"2023-11-20T01:33:32","guid":{"rendered":"https:\/\/bionauts.jp\/?p=3235"},"modified":"2023-11-27T10:38:01","modified_gmt":"2023-11-27T01:38:01","slug":"novel-steroid-hormone-membrane-receptor-antagonist-for-side-effect-free-contraceptives","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=3235","title":{"rendered":"Novel steroid hormone  membrane receptor antagonist  for side effect-free contraceptives"},"content":{"rendered":"<h3>Advantages<\/h3>\n<ul>\n<li><strong>New Approaches to Contraceptives Without Side Effects, an Increasingly Needed Contraceptive<\/strong><\/li>\n<li><strong>Demonstration in fish completed and in mice also nearing completed and release<\/strong><\/li>\n<li><strong>Substance obtained by HSP with inventor<\/strong><strong>\u2018<\/strong><strong>s original synthetic mPR protein<\/strong><\/li>\n<\/ul>\n<h3>Current Stage &amp; Goals<\/h3>\n<p>Conventional contraceptives are progesterone-like compounds, a group of substances with a steroidal skeleton. Thus, they do not escape the side effects of steroidal compounds, which generally cause nausea, vomiting, dizziness, fatigue, headache, breast tenderness, and lower abdominal pain, but no drug has been brought to avoid them.<br \/>\nThe inventor has long studied the effects of steroid hormones on living organisms. The present inventor has focused his research on the plasma membrane progesterone receptor (mPR), which transmits non-genomic action to cells. In the process, they have recently succeeded in artificial synthesis of mPR protein, which enables to screen substances acting on the mPR receptor in a high-throughput manner. On the other hand, the inventor has promoted research on extracts purified from seawater collected in marine waters where seaweed <em>Padina<\/em> inhabit for the purpose of investigating the effects of environmental hormones on fish, and has worked to purify the compounds from the seaweed <em>Pandia<\/em>. Through an approach that linked these research themes, it was revealed that a compound purified from the <em>Pandia<\/em> acts as an antagonist to the mPR receptor. Nuclear magnetic resonance (NMR) analysis of this extract demonstrated that it contained 2-hydroxypentanoic acid (2-HPA) and that it inhibits oocyte maturation and ovulation in fish.<\/p>\n<table style=\"border-collapse: collapse; width: 32.8333%; height: 216px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588a.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-3242 size-full\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588a.jpg\" alt=\"\" width=\"242\" height=\"200\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Data<\/h3>\n<ul style=\"list-style-type: disc;\">\n<li>Inhibition of oocyte maturation and ovulation by 2-HPA and its analogs in zebrafish<\/li>\n<\/ul>\n<p style=\"padding-left: 40px;\">Compared to 2-HPA, 2-Hydroxybutyric acid, valeric acid, 2-Hydroxyhexanoic acid, 1,2-Pentanediol, and 3-Hydroxyvaleric acid hydroxyvaleric acid, and 1,2-pentanediol were used. Only 2-HPA can inhibit oocyte maturation and ovulation in zebrafish.<\/p>\n<table style=\"border-collapse: collapse; width: 53.3333%; height: 242px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-3236\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588.png\" alt=\"\" width=\"558\" height=\"491\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588.png 558w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/11\/ON-04588-300x264.png 300w\" sizes=\"(max-width: 558px) 85vw, 558px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Patent<\/h3>\n<p>Pending (unpublished)<\/p>\n<h3>Publication<\/h3>\n<p>[1] Tokumoto T,et al.,<em>Research Square<\/em>\u00a0 <a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-3360164\/v1\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.21203\/rs.3.rs-3360164\/v1<\/a><br \/>\n[2] Tokumoto T,et al.,<em>Biochemical and Biophysical Research Communications <\/em>592 (2022)1-6<\/p>\n<h3>Applicant<\/h3>\n<p>National University Corporation Shizuoka University<\/p>\n<h3>Researcher<\/h3>\n<p>Department of Bioscience, Graduate School of Integrated Science and Technology, Shizuoka University<br \/>\nProfessor Toshinobu Tokumoto<\/p>\n<h3>Development Phase<\/h3>\n<p>Current stage:<br \/>\nProof of concept of 2-HPA inhibiting ovulation and oocyte maturation has been completed (mouse proof of concept will be released by the end of the year).<\/p>\n<p>Next stage:<br \/>\n1)Detailed mechanism research, other proof of concept, formulation optimization development<br \/>\n2)Clinical development<\/p>\n<p>We are looking for a development partner company that can help us advance the above development. We would be happy to start with a detailed explanation and discussion of the technology.<\/p>\n<p>&nbsp;<\/p>\n<p>Project No.ON-04588<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Substance derived from seaweed \u201cPadina extract\u201d 2-hydroxypentanoic acid<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[101,96],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3235"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3235"}],"version-history":[{"count":5,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3235\/revisions"}],"predecessor-version":[{"id":3243,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/3235\/revisions\/3243"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3235"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3235"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=3235"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=3235"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=3235"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=3235"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=3235"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=3235"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=3235"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=3235"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=3235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}