{"id":2938,"date":"2023-07-20T15:37:47","date_gmt":"2023-07-20T06:37:47","guid":{"rendered":"https:\/\/bionauts.jp\/?p=2938"},"modified":"2023-07-20T15:37:47","modified_gmt":"2023-07-20T06:37:47","slug":"novel-cancer-immunotherapy-antibodies-targeting-soluble-cd155","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=2938","title":{"rendered":"Novel cancer immunotherapy antibodies targeting soluble CD155"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Mechanism induces activation of immune cells rather than inhibition of inhibitory receptors such as PD-1 and CTLA4<\/li>\n<li>Expected to enhance the effects of immune checkpoint inhibitors when used in combination<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<table style=\"border-collapse: collapse; width: 59.3333%; height: 157px;\">\n<tbody>\n<tr style=\"height: 200px;\">\n<td style=\"width: 100%; height: 200px;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746a-1.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft wp-image-2941\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746a-1.png\" alt=\"\" width=\"312\" height=\"167\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746a-1.png 434w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746a-1-300x160.png 300w\" sizes=\"(max-width: 312px) 85vw, 312px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>To develop cancer immunotherapy, it is important to clarify the immune surveillance against tumor cells by the immune system and the escape mechanisms from immune surveillance by tumor cells.<br \/>\nInventors have previously found that the T-cell activating receptor DNAM-1 is responsible for immune surveillance against tumor cells by binding to CD155 on tumor cells and killing them.<br \/>\nUnlike mouse CD155, a soluble form of human CD155 exists due to a splicing variant that lacks a transmembrane site. When a soluble CD155-producing cancer cell line (sCD155-MethA) was generated and transferred into mice, rapid tumor growth and reduced survival were observed compared to a non-producing cancer cell line (Mock-MethA). On the other hand, transfer of these cell lines into DNAM-1 gene-deficient mice showed no difference in carcinogenicity and survival, indicating that tumor cells escape immune surveillance by DNAM-1 by producing sCD155. Furthermore, soluble CD155-producing cancer cell lines were shown to attenuate the effects of immune checkpoint inhibitors.<br \/>\nSpecific antibodies against sCD155 were established by the inventors, and the anti-tumor effect of these antibodies on soluble CD155-producing cancer cell lines was demonstrated. The anti-tumor effect of this antibody was mediated by activation of CD8-positive T cells.<\/p>\n<h3>Data<\/h3>\n<table style=\"border-collapse: collapse; width: 102.167%; height: 40px;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-2943\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1.png\" alt=\"\" width=\"4075\" height=\"1050\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1.png 4075w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-300x77.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-1024x264.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-768x198.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-1536x396.png 1536w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-2048x528.png 2048w, https:\/\/bionauts.jp\/wp-content\/uploads\/2023\/07\/WL-02746d-1-1200x309.png 1200w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul>\n<li>Values of sCD155 in serum of cancer patients and healthy subjects (A). In all cancer types analyzed, sCD155 in cancer patient serum was significantly higher than in healthy controls.<\/li>\n<li>Carcinogenicity and survival of sCD155-producing tumor lines (sCD155-MethA) and control tumor lines (Mock-MethA) when transferred into wild-type (B) DNAM-1 KO mice (C)<\/li>\n<\/ul>\n<h3>Patent &amp; Publication<\/h3>\n<p>JPB 5850508, JPB 5686361, JPB 5995117<br \/>\nPLOS ONE (<a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0152982\">DOI: 10.1371\/journal.pone.0152982<\/a>),<br \/>\nJ Exp Med (<a href=\"https:\/\/rupress.org\/jem\/article\/217\/4\/e20191290\/133708\/Tumor-derived-soluble-CD155-inhibits-DNAM-1\">doi.org\/10.1084\/jem.20191290<\/a>)<\/p>\n<h3>Researcher<\/h3>\n<p>Dr. Kazuko Shibuya, Dr. Akira Shibuya (University of Tsukuba)<\/p>\n<h3>Expectations<\/h3>\n<p>We are looking for companies that are interested in developing therapeutics based on specific antibodies against sCD155 established by the inventor. In particular, we are looking to collaborate with companies that have antibody technology that improves the activity of specific antibodies to remove sCD155. Data on the established antibodies can be disclosed under a CDA.<\/p>\n<p>&nbsp;<\/p>\n<p>Project No. WL-02746<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Targeting soluble CD155, an immune escape mechanism of tumor cells, activates cancer immunity through DNAM-1-mediated activation signals on T cells<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[102,103,121,112],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2938"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2938"}],"version-history":[{"count":4,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2938\/revisions"}],"predecessor-version":[{"id":2946,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2938\/revisions\/2946"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2938"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2938"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2938"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=2938"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=2938"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=2938"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=2938"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=2938"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=2938"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=2938"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=2938"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=2938"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}