{"id":2154,"date":"2022-04-22T14:22:40","date_gmt":"2022-04-22T05:22:40","guid":{"rendered":"https:\/\/bionauts.jp\/?p=2154"},"modified":"2024-10-15T14:20:38","modified_gmt":"2024-10-15T05:20:38","slug":"monoclonal-antibody-for-neuropathic-pain","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=2154","title":{"rendered":"Monoclonal Antibody for Neuropathic Pain"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Anti-human netrin-4 mouse antibodies cross-react with non-human netrin-4.<\/li>\n<li>Nerve root injection, commonly used in pain clinic, with small dose applicable.<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>Our researcher has revealed that neuropathic pain signaling is mediated by Netrin-4 and its receptor Unc5B, and demonstrated that blockade of Netrin-4-Unc5B signals by siRNA or polyclonal antibody intrathecal administration can alleviate the neuropathic pain in 2016 (fig. L, publications).<br \/>\nNow, he identified the epitope of Netrin-4, and obtained monoclonal antibodies by mouse immunization with peptide whose sequence is common in human and rodent. Dorsal root administration experiment showed efficacy, which indicated the mAb could make a medicine with novel mechanism for patients with hyperalgesia or allodynia after nerve injury.<\/p>\n<h3>Data<\/h3>\n<ul>\n<li>In rat von Frey Filament test model, 3\u03bcg anti-netrin-4 mAb injection into dorsal root 7days after partial sciatic nerve ligation elevated the withdrawal threshold to the contra-lateral level (Fig. R).<\/li>\n<li>Obtained humanized mAb and confirmed effect by systemic administration (not published).<\/li>\n<\/ul>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 50%;\"><img decoding=\"async\" loading=\"lazy\" class=\"size-medium wp-image-2156 alignleft\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/29d3bc99193cb0b837fb8cc53f050ae5-2-300x290.png\" alt=\"\" width=\"300\" height=\"290\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/29d3bc99193cb0b837fb8cc53f050ae5-2-300x290.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/29d3bc99193cb0b837fb8cc53f050ae5-2.png 529w\" sizes=\"(max-width: 300px) 85vw, 300px\" \/><\/td>\n<td style=\"width: 50%;\"><img decoding=\"async\" loading=\"lazy\" class=\" wp-image-2157 alignleft\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/cbf5b9f60da99bf791c0aa12a770f429-1-300x202.png\" alt=\"\" width=\"347\" height=\"235\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/cbf5b9f60da99bf791c0aa12a770f429-1-300x202.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2022\/04\/cbf5b9f60da99bf791c0aa12a770f429-1.png 329w\" sizes=\"(max-width: 347px) 85vw, 347px\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Patent, Publications<\/h3>\n<ul style=\"list-style-type: disc;\">\n<li>Background Patent: WO2015\/025770, registered in US\/EP\/JP<\/li>\n<li>Monoclonal antibody patent: WO2023\/190496 applied in US\/EP\/JP.<\/li>\n<li>Journal: <a href=\"https:\/\/doi.org\/10.1073\/pnas.1402095111\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1073\/pnas.1402095111<\/a>, <a href=\"https:\/\/doi.org\/10.1084\/jem.20160877\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1084\/jem.20160877<\/a><\/li>\n<\/ul>\n<h3>Researcher<\/h3>\n<p>Prof. Toshihide YAMASHITA (Osaka Univ. JAPAN)<\/p>\n<h3>Expectations<\/h3>\n<p>We are seeking a partner who will in-license and develop the technology further by humanization of mAbs. Details can be disclosed under CDA, mAbs for review can be provided under MTA (paid).<\/p>\n<p>Project No. KJ-04225<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Blockade of novel target, Netrin-4 Unc5B signaling.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[102,104],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2154"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2154"}],"version-history":[{"count":8,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2154\/revisions"}],"predecessor-version":[{"id":3969,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/2154\/revisions\/3969"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2154"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=2154"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=2154"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=2154"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=2154"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=2154"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=2154"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=2154"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=2154"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=2154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}