{"id":1968,"date":"2021-12-13T10:54:10","date_gmt":"2021-12-13T01:54:10","guid":{"rendered":"https:\/\/bionauts.jp\/?p=1968"},"modified":"2022-05-16T15:59:34","modified_gmt":"2022-05-16T06:59:34","slug":"proposal-for-license-and-co-development-of-devices-capable-of-high-speed-68ga-separation-and-purification-as-well-as-automated-drug-synthesis","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=1968","title":{"rendered":"Proposal for license and co-development of devices capable of high-speed 68Ga separation and purification as well as automated drug synthesis"},"content":{"rendered":"<h3>Advantage<\/h3>\n<ul>\n<li>1\/10-1\/3 the processing time of conventional methods<\/li>\n<li>Fully closed flow process from separation, purification, and concentration to drug synthesis<\/li>\n<li>Ga yield is over 99%<\/li>\n<li>Recovery and recycling of metal Zn after removal is also possible<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>PET(Positron Emission Tomography) is a high-resolution, non-invasive diagnostic imaging technology that uses radioisotopes as markers. So far, <sup>18<\/sup>F-FDG using fluorine-<sup>18<\/sup>F has been widely used for the diagnosis of cancer, but there is a need to utilize other radionuclides because <sup>18<\/sup>F-FDG is not optimal for some tumors and because of the short half-life of <sup>18<\/sup>F(109.4 minutes).As such Radio isotope,\u3000<sup>68<\/sup>Ga have been developed as radiopharmaceuticals. Specifically, <sup>68<\/sup>Ga-DOTATATE for neuroendocrine tumors and <sup>68<\/sup>Ga-PSMA for prostate cancer have been clinically applied to PET\/CT, and demand for them is expanding on a global scale. As for <sup>68<\/sup>Ga production equipment, Ge\/Ga generators have also been approved as small and simple equipment, but the yield of this process is still low, and there are few production sites, so there is a high possibility that supply will be insufficient to meet the growing demand.<\/p>\n<p>Based on the ion extraction devices that our group has been studying for many years, we have designed a device that simultaneously achieves \u201csubstitution by acid matrix\u201d \u201cselective complexation reaction\u201d \u201cin-line concentration\u201d and have completed this process. This process has been showed to be sufficient for the recovery of trace amounts of fg(10<sup>-15<\/sup>)\u3001pg(10<sup>-12<\/sup>) radioisotopes.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-large wp-image-1970\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/29d3bc99193cb0b837fb8cc53f050ae5-1-1024x468.png\" alt=\"\" width=\"840\" height=\"384\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/29d3bc99193cb0b837fb8cc53f050ae5-1-1024x468.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/29d3bc99193cb0b837fb8cc53f050ae5-1-300x137.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/29d3bc99193cb0b837fb8cc53f050ae5-1-768x351.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/29d3bc99193cb0b837fb8cc53f050ae5-1-1200x548.png 1200w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/p>\n<h3>Data<\/h3>\n<ul>\n<li>A sample solution (1.9\uff4dL) with pH adjustment and EDTA addition was placed in a loop and two valves were switched to recover high concentration Ga &gt;99\uff05 with Zn removed by fraction collection time.<\/li>\n<\/ul>\n<p>Sample solution\uff1d50fg<sup>67<\/sup>Ga\/L\uff0b0.1gZn\/L (containing <sup>65<\/sup>Zn as tracer)<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-1969\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/cdbc96afa400842eb05459bd1a63f60d.png\" alt=\"\" width=\"958\" height=\"550\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/cdbc96afa400842eb05459bd1a63f60d.png 958w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/cdbc96afa400842eb05459bd1a63f60d-300x172.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/12\/cdbc96afa400842eb05459bd1a63f60d-768x441.png 768w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/p>\n<h3>Patent<\/h3>\n<p>Pending<\/p>\n<h3>Inventors<\/h3>\n<p>&nbsp;<\/p>\n<p>Shinichi Ohira, Takashi Toda \u00a0(Kumamoto University)<br \/>\nYumi Sugo\u00a0 (National Institutes for Quantum Science and Technology)<br \/>\nKatsunobu Mori\u00a0 (Kochi University)<\/p>\n<h3>Development Stage<\/h3>\n<p>-Current stage\uff1a The basic principle has been confirmed and the separation, purification and recovery performance of the device has been demonstrated with an experimentally available\u00a0 radioisotope (<sup>67<\/sup>Ga\/<sup>65<\/sup>Zn).<\/p>\n<p>&nbsp;<\/p>\n<p>-Next stage\uff1aDemonstration of the reproducibility of <sup>\u00a068<\/sup>Ga\/<sup>68<\/sup>Zn in this system. Development and demonstration of a flow system for drug synthesis.<\/p>\n<p>&nbsp;<\/p>\n<p>We are looking for co-development partners for the next stage of development of practical devices. We would be happy to start with a detailed explanation and discussion of this process.<\/p>\n<p>&nbsp;<\/p>\n<p>Please feel free to ask us about the application and practical use of this technology for the separation, purification, removal, and recycling of other radioactive isotopes and\u00a0 metals.<\/p>\n<p>Product No. ON-04099<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A system that makes it possible to synthesize drugs from cyclotron-irradiated solutions with Ga-68 using a hands-free ion trapping device<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[],"other_than_medicine":[],"material":[],"engineering":[157,156],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1968"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1968"}],"version-history":[{"count":1,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1968\/revisions"}],"predecessor-version":[{"id":1971,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1968\/revisions\/1971"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1968"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1968"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1968"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=1968"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=1968"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=1968"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=1968"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=1968"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=1968"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=1968"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=1968"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=1968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}