{"id":1759,"date":"2021-05-27T12:18:50","date_gmt":"2021-05-27T03:18:50","guid":{"rendered":"https:\/\/bionauts.jp\/?p=1759"},"modified":"2023-04-20T15:01:41","modified_gmt":"2023-04-20T06:01:41","slug":"ornithine-nanoparticle-for-suppression-of-liver-damage-in-hyperammonemia","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=1759","title":{"rendered":"Ornithine\/Arginine Nanoparticles for Suppressing Liver Damage in Hyperammonemia"},"content":{"rendered":"<h3>Advantages<\/h3>\n<ul>\n<li>Once-daily oral administration keeps high blood concentration for 24h.<\/li>\n<li>Potential application for NASH\/NAFLD related liver dysfunction as well as hyperammonemia, hepatic encephalopathy.<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>Ornithine is known as a key amino acid on ammonia metabolism, and L-ornithine L-asparatate complex (LOLA: Hepa-Merz) is used as supplement for improving liver function, and as therapeutics for hyperammonemia that causes hepatic encephalopathy in Europe. On the other hand, ornithine is metabolized quickly and is low bioavailability by oral administration. The researcher synthesized the self-assembling ornithine nanoparticles by formulating poly block co-polymer of poly-ornithine and polyethylene glycol (PEG). Orally administered ornithine nanoparticles accumulate in intestinal mucosa and gradually release ornithine into the bloodstream over 24 hours.<br \/>\nThe ornithine nanoparticles can suppress liver dysfunction and reduce blood ammonia concentration, and maintain liver function. Arginine nanoparticles were also synthesized. Arginine replacement is considered to be effective for treatment of ureacycle disorders and cancers.<br \/>\nHyperammonemia, which is deteriorating factor of non-alcoholic fatty disease (NAFLD) causes hepatic encephalopathy.<\/p>\n<h3>Data<\/h3>\n<p>Therapeutic effects were examined in APAP (acetaminophen) induced acute liver injury mouse model. Once daily orally administered nanoparticles with 200mg\/kg ornithine, NOT ornithine, reduced blood ammonia concentration(fig. R), hepatocyte necrosis(fig. L), and improved hepatic function (ALT, AST, etc.). Nanoparticles significantly improved survival as compared to L-ornithine.<br \/>\nArginine nanoparticles have \u00a0significantly reduced triglyceride level in mouse NASH model.<\/p>\n<table style=\"border-collapse: collapse; width: 108.167%; height: 234px;\">\n<tbody>\n<tr style=\"height: 234px;\">\n<td style=\"width: 1.54083%; height: 234px;\"><\/td>\n<td style=\"width: 65.1258%; height: 234px;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824a-1.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-2774\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824a-1.png\" alt=\"\" width=\"940\" height=\"387\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824a-1.png 940w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824a-1-300x124.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824a-1-768x316.png 768w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/a><\/td>\n<td style=\"width: 33.3333%; height: 234px;\"><a href=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824b.png\"><img decoding=\"async\" loading=\"lazy\" class=\"alignleft size-full wp-image-2775\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824b.png\" alt=\"\" width=\"516\" height=\"538\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824b.png 516w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/05\/KJ-03824b-288x300.png 288w\" sizes=\"(max-width: 516px) 85vw, 516px\" \/><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u25c6Nanoorn(iBu) :<br \/>\nisobutyryl group-hydrophobized poly-L-ornithine PEG block copolymer self- assembly.<\/p>\n<h3>Patent<\/h3>\n<p>Pending (WO2022\/102608A1) (US, EP, CN, JP)<\/p>\n<h3>Researcher<\/h3>\n<p>Professor Yukio Nagasaki, Faculty of Pure and Applied Sciences, University of Tsukuba<\/p>\n<h3>Expectations<\/h3>\n<p>&#8211; We are seeking companies to license and commercialize this technology.<br \/>\n&#8211; Samples can be provided under MTA.<\/p>\n<p>&nbsp;<\/p>\n<p>Project No\uff1aKJ-03824<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Advantages Once-daily oral administration keeps high blood concentration for 24h. Potential application for NA &hellip; <a href=\"https:\/\/bionauts.jp\/?p=1759\" class=\"more-link\"><span class=\"screen-reader-text\">&#8220;Ornithine\/Arginine Nanoparticles for Suppressing Liver Damage in Hyperammonemia&#8221; \u306e<\/span>\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[50,46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[147,101,121,96],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1759"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1759"}],"version-history":[{"count":8,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1759\/revisions"}],"predecessor-version":[{"id":2776,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1759\/revisions\/2776"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1759"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=1759"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=1759"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=1759"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=1759"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=1759"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=1759"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=1759"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=1759"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=1759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}