{"id":1735,"date":"2021-03-16T15:47:01","date_gmt":"2021-03-16T06:47:01","guid":{"rendered":"https:\/\/bionauts.jp\/?p=1735"},"modified":"2021-03-16T15:47:01","modified_gmt":"2021-03-16T06:47:01","slug":"anti-cd155-antibody-treatment-for-th1-type-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/bionauts.jp\/?p=1735","title":{"rendered":"Anti-CD155 antibody treatment for Th1 type autoimmune diseases"},"content":{"rendered":"<h3>Advantage and Core Benefit<\/h3>\n<ul>\n<li>Expected to have fewer side effects than immunosuppressive drugs that suppress normal immune responses<\/li>\n<li>Specific treatment of Th1 immune disorders such as contact dermatitis is possible<\/li>\n<\/ul>\n<h3>Background and Technology<\/h3>\n<p>Th1 cells are mainly induced by IFN-\u03b3 and IL-12, produce IFN-\u03b3 and IL-2, activate macrophages, and are involved in the elimination of intracellular parasites and inflammatory diseases. Dr. Shibuya\u2019s group found that CD155 on CD4+ T cells acts as a co-stimulatory molecule, induces differentiation of na\u00efve T cells into Th1 cells (left panel), and is involved in the pathogenesis of Th1 immune diseases.<br \/>\nBy using CD155 inhibitory antibodies, the Th1\/Th2 balance was tilted towards Th2, and the therapeutic effect on contact hypersensitivity (CHS), one of the Th1-type immune diseases, was found (right panel).<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 100%;\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-large wp-image-1736\" src=\"http:\/\/bionauts.jp\/wp-content\/uploads\/2021\/03\/c1f4f94d082ec7646287abd708145e3d-1-1024x320.png\" alt=\"\" width=\"840\" height=\"263\" srcset=\"https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/03\/c1f4f94d082ec7646287abd708145e3d-1-1024x320.png 1024w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/03\/c1f4f94d082ec7646287abd708145e3d-1-300x94.png 300w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/03\/c1f4f94d082ec7646287abd708145e3d-1-768x240.png 768w, https:\/\/bionauts.jp\/wp-content\/uploads\/2021\/03\/c1f4f94d082ec7646287abd708145e3d-1.png 1093w\" sizes=\"(max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>Data<\/h3>\n<ul>\n<li>CD155 co-stimulation promoted the differentiation of naive CD4+T cells into Th1 cells (human and mouse)<\/li>\n<li>Treatment with CD155 ligand-binding inhibitory antibodies has a therapeutic effect in a model of contact dermatitis (Type 5 allergy).<\/li>\n<\/ul>\n<h3>Patent and Publishment<\/h3>\n<p>JP 6296650 (Granted)<br \/>\nY. Kanemaru et. al. J. Immunology (2015)<br \/>\nDOI: https:\/\/doi.org\/10.4049\/jimmunol.1401942<\/p>\n<h3>Researcher<\/h3>\n<p>Dr, Kazuko Shibuya and Dr. Akira Shibuya (Tsukuba University)<\/p>\n<h2>Expectations<\/h2>\n<p>We are looking for companies interested in developing therapeutics based on the mechanism of Th1\/Th2 immune balance regulation by CD155. Co-development of humanized antibodies and collaborations for Th1 immune diseases are welcome. mCD155 antibody (TX56: rat IgG) hCD155 antibody (TX28: mouse IgG) MTA is available.<\/p>\n<p>Product No. WL-03746<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Treatment of immunological diseases by a new mechanism to control the immune Th1\/Th2 balance<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"categories":[1],"tags":[],"categories_of_inventions":[46],"disease_categories___indication":[],"asset_type":[],"development_phase":[],"medicine":[102,104],"other_than_medicine":[],"material":[],"engineering":[],"software_it":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1735"}],"collection":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1735"}],"version-history":[{"count":1,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1735\/revisions"}],"predecessor-version":[{"id":1737,"href":"https:\/\/bionauts.jp\/index.php?rest_route=\/wp\/v2\/posts\/1735\/revisions\/1737"}],"wp:attachment":[{"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1735"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1735"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1735"},{"taxonomy":"categories_of_inventions","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories_of_inventions&post=1735"},{"taxonomy":"disease_categories___indication","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdisease_categories___indication&post=1735"},{"taxonomy":"asset_type","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fasset_type&post=1735"},{"taxonomy":"development_phase","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fdevelopment_phase&post=1735"},{"taxonomy":"medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedicine&post=1735"},{"taxonomy":"other_than_medicine","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fother_than_medicine&post=1735"},{"taxonomy":"material","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmaterial&post=1735"},{"taxonomy":"engineering","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fengineering&post=1735"},{"taxonomy":"software_it","embeddable":true,"href":"https:\/\/bionauts.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fsoftware_it&post=1735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}