Inserting 50-nucleotide synthetic repeat sequences into the 5’UTR significantly enhances mRNA translation, achieving up to 10-fold increases in protein expression in both cells and animals
A Novel Drug Discovery Approach Targeting a Macrophage-Derived Cytokine and Its Downstream Molecules That Induce Cartilage Destruction
D35LNPs stimulate TLR9 and significantly induce the release of IFN-α from plasmacytoid dendritic cells, thereby strongly enhancing systemic immunity
RNA-binding molecules, such as antisense oligonucleotides and small molecules, facilitate back-splicing progression and augment circular RNA
Newly designed KK-(EK)4-lipid having near neutral charge enhances intracellular translocation of drug carrier
Overcoming the challenges of mRNA medicine by improving translation efficiency
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