Suppression of epidermal cell death through control of necroptosis by chenodeoxycholic acid
Erythromycin binds to CUG-expanded RNA to suppress RNA toxicity and splicing misregulation in DM1.
The approved antihistamine meclizine promotes cartilage formation by suppressing excessive signaling caused by FGFR3 mutations.
Orally available nanoparticles containing BCAA peptides
Discovery of a new mechanism of hypertension induction and proposal for drug discovery collaboration based on the mechanism.
New therapeutic targets and therapeutic agents for trauma-induced heterotopic ossification in FOP patients.
An approach to enhance mechanical stress responsiveness via activation of Piezo1 shows promise in improving bone mass and strength in patients with glucocorticoid-induced osteoporosis (GIOP).
Small molecule compounds (CRY1-A and CRY2-A) that selectively inhibit and activate the circadian clock regulators CRY1 and CRY2, respectively.
Orally available micelle-type branched-chain amino acid prodrug
Improvement of cilial dysfunction by FGFR inhibitor through ICK/MAK pathway activation.
Identification of prostaglandin receptors involved in the pathogenesis of endometriosis. [Collaborative Research Proposal]
Substance derived from seaweed “Padina extract” 2-hydroxypentanoic acid
Runx2 expression was specifically induced in osteoblasts. Bone volume was increased through the enhanced bone formation in mice.
Original method and hepatocyte reproduced hepatobiliary function
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