Biomarker to distinguish *AOSD from Sepsis

*AOSD: Adult onset Still’s disease

Advantages

High sensitivity, specificity and accuracy

Background

The precise cytokine networks in the serum of individuals with AOSD (adult onset Still’s disease) that are associated with its pathogenesis have been unknown.  Serum levels of IL-1beta, IL-6 and IL-18 have been reported as useful serum biomarkers for diagnosis and disease evaluation among AOSD patients, but these cytokines are also elevated in other inflammatory diseases including severe infection.  For example, it is reported that serum IL-18 level was elevated in septic patients compared to healthy adults [J Clin Immunol. 2000 May;20(3):212-5.].

Technology Overview with Data

Serum fibroblast growth factor 2 (FGF-2), vascular endothelial growth factor (VEGF), granulocytecolony stimulating factor (GM-CSF), IL-17 and IL-18 levels were significantly elevated in the AOSD group versus the sepsis group.  Multivariate classification algorithms followed by a logistic regression analysis revealed that the measurement FGF-2 distinguished AOSD patients from sepsis patients with high accuracy (cut-off value = 35.5 pg/mL, sensitivity 88.3 %, specificity 88.2 %, accuracy 88.3%).

Patents

Applied in Japan and pending.

PCT application has not been decided.

Publications

1. Academic Conference(s): – Annual European Congress of Rheumatology (Amsterdam, 13-16 June 2018)

2. Paper(s): – Submitted.

Researchers & Academic Institutions

Tomohiro Koga, MD, PhD (Nagasaki University, Japan), Shuntaro Sato, PhD (Nagasaki University, Japan), Prof. Kiyoshi Migita, MD, PhD (Fukushima Medical University, Japan), and Prof. Atsushi Kawakami, MD, PhD (Nagasaki University, Japan)

Further Details

CDA (with Nagasaki University) — Available

MTA (with Nagasaki University; for patient samples) — Not available

Expectations

We, Tech Manage Corp. is now looking for a pharmaceutical/diagnostics company to develop a novel diagnosing kit/tool/device by using this technology further under the licensing.

Product No:TP-00804

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